Best Strains for Pain and Fatigue

Best Strains for Pain and Fatigue

Many conditions cause pain and fatigue. Whatever your ailments are, cannabis can help. Read to find out the best strains for pain and fatigue.

Best Strains for Pain and Fatigue

Pain and fatigue are common afflictions. In fact, it is estimated that 50 million adults suffer from chronic pain and fatigue (CDC). Pain and fatigue can be very problematic in people’s everyday lives. It can affect people’s ability to work, care for themselves, and more. 

Cannabis has been known to relieve these symptoms. In this article, we will list the most common causes of pain and fatigue. Secondly, we will discuss how cannabis can soothe those problems. Next, we will list the best strains for pain and fatigue, and how JANE can help.

Common Causes of Pain and Fatigue

There are many illnesses that cause pain and fatigue. Some of the most common include: 

  • Cancer
  • Chronic Fatigue Syndrome
  • Inflammation
  • Fibromyalgia
  • Arthritis
  • Depression
  • Lupus
  • Diabetes

This is not an exhaustive list. There are many conditions that cause pain and fatigue. However, there are many medical marijuana uses for treating these symptoms. Cannabis is an all natural and highly effective way to treat pain and fatigue without opioids.

How Cannabis Treats Pain and Fatigue

Cannabis for treating pain and fatigue

Cannabis treats pain and fatigue in several different ways. It utilizes the body’s own endocannabinoid system to send and receive signals. This signaling system is important in reducing pain and fatigue. Also, the cannabinoids CBD vs THC react differently in the body to provide relief. 

For example, cannabinoid receptors and CBD respond uniquely in the endocannabinoid system. They weakly bind together but increase the number of endocannabinoids. Furthermore, CBD contains immune receptors called CB2, which regulates and boosts immunity. This has the added benefit of treating pain by reducing inflammation. Also, CBD can influence serotonin receptors. As a result, CBD is able to boost mood and reduce the sensation of pain. In addition, CBD is beneficial for fighting fatigue. It is able to help improve sleep, reduce stress, and increase wakefulness. Therefore, many people are turning to CBD oil for pain and energy. 

Conversely, THC binds to cannabinoid receptors and contains the psychoactive ingredient. As a result, it produces euphoria, which helps to dull the perception of pain. Furthermore, THC interferes with pain signaling. This reduces the amount of pain a person feels. THC also has anti-inflammatory effects and helps treat conditions such as neuropathic pain. At the same time, cannabis treats underlying causes for fatigue and can increase energy. It helps by treating insomnia, nausea, and stress. When people don’t eat enough calories, they can feel very fatigued. By stimulating appetite, people feel less tired. In addition, sleep deprivation is a common cause of fatigue. Marijuana for insomnia has been studied and shown to be effective. As a result, THC is a useful treatment for pain and fatigue. 

Best Strains for Pain and Fatigue

Typically, sativa or sativa dominant strains will be the best choice for treating these symptoms. Indicas tend to be sedating, and will be a poor choice for fighting fatigue. Here are the top 5 best strains for fighting pain and fatigue.

Strawberry Diesel

Strawberry Diesel is a near perfect hybrid, meaning nearly 50% indica and 50% sativa. In addition, this strain contains about 20% THC and low CBD. Although it is a hybrid, it tends to produce sativa effects. It provides the user with increased energy, a rush of euphoria, and an energy boost. However, like a hybrid, it provides a balanced mind and body high. It is incredibly useful for pain management as well. It soothes muscle spasms, relieves stress, and eases chronic pain. As a bonus, this strain also has a strawberry taste. This strain works quickly and its effects are long lasting. 

Durban Poison

This strain is well known for its energy benefits. It is a sativa strain that has about 22% THC and 1% CBD. Although its energy-giving properties are legendary, it also reduces pain. Many people use this strain for migraines and relief from depression. Its high THC content also makes it an ideal choice for moderate to severe pain. However, this strain is quite strong and should not be used at nighttime. This is a favorite strain for medical marijuana patients and gives an intensely euphoric high. As a result, this is one of the best strains for pain and fatigue. 


Harlequin is another favorite strain for medical marijuana patients. It is a unique sativa dominant hybrid that has strong indica properties. This strain contains 10% THC and 15% CBD. Although this strain is not as strong as some, especially California strains, it is highly effective. Harlequin provides a relaxing, clear headed and uplifted high. In addition, this strain provides a boost of energy and focus. As a result, people who use this strain benefit from its pain relieving qualities as well as its energy effects. Best uses for this strain include: chronic fatigue, stress, and pain.

Tangerine Power

This strain is a sativa dominant hybrid that has a wonderful orange taste. It contains 19% THC and 1% CBD. Tangerine Power is beneficial for patients with muscle spasms, pain disorders, fatigue and stress. Consumers can expect to feel euphoria and an increase in energy. Furthermore, this strain provides the creativity and focus of a typical sativa strain. Many people choose this strain for a “wake and bake” option as well. For people with chronic pain, nausea, anxiety, and stress, this is an excellent choice.  

White Fire OG

This relatively unknown strain is also known as “Wifi OG” or “Wifi.” It is a sativa dominant hybrid strain that has a very high THC level. Typically, it ranges from 22-28%. As a result, this strain is best for regular cannabis consumers. This strain provides a strong rush of euphoria, energy, and a cerebral high. At the same time, most people experience a clear head and can still perform activities. White Fire OG is an excellent choice for medical marijuana patients. It treats anxiety, cancer, and glaucoma pain, and stimulates appetite. In addition, people with chronic pain and fatigue enjoy this strain for its benefits.

There are many strains that help relieve pain and fatigue. Cannabis consultants at JANE Dispensary can assist you in choosing the right strains for these symptoms. Please consult them if you have any questions.


JANE Dispensary is an online dispensary with in-store pickup and delivery options. We have two beautiful locations to serve you. Check out our Santa Rosa dispensary and our Cotati Dispensary today!


Note: This is an informational article. This is not intended as medical advice. Please consult your doctor.


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